Related Experiment Video
Updated: May 1, 2026
03:49
Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse POP Quantification System
Published on: September 20, 2018
20.8K
Advanced maternal age and obstetric outcome.
Nepal Medical College Journal : NMCJ
|April 5, 2014
Summary
Pregnancy in women aged 35 and older (advanced maternal age) is linked to more complications. These include hypertensive disorders and higher rates of C-sections and perinatal death compared to younger women.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Reproductive Health
Background:
- Advanced maternal age (≥35 years) is associated with increased obstetric complications and adverse pregnancy outcomes.
- Understanding these risks is crucial for optimizing maternal and infant care.
Purpose of the Study:
- To compare obstetric and perinatal outcomes in pregnancies among women aged 35 years or older versus younger women (<35 years).
Main Methods:
- A prospective comparative study involved 90 women aged ≥35 years and 90 women aged 20-34 years.
- Outcomes were assessed over a one-year period at Nepal Medical College and Teaching Hospital.
Main Results:
- Women of advanced maternal age showed significantly higher incidence of hypertensive disorders of pregnancy (26.6% vs 4.4%) and breech presentation (8.8% vs 1.1%).
- Cesarean delivery rates were higher in the advanced maternal age group (28.8% vs 17.7%).
- Perinatal death rates were significantly higher in older women (7.7% vs 0%).
Conclusions:
- Advanced maternal age is associated with increased risks of hypertensive disorders, malpresentation, cesarean delivery, and perinatal death.
- These findings highlight the need for careful monitoring and management of pregnancies in older women.
Related Concept Videos
02:07Oogenesis
58.4K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
58.4K
01:21Nondisjunction
4.5K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
4.5K
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
861
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
861
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
367
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
367