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Mesenchymal stem cells and transplant tolerance

Aruna V Vanikar1, Hargovind L Trivedi, Ashutosh Kumar

  • 1Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Centre (IKDRC) - Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, India.

Nephrology (Carlton, Vic.)
|April 5, 2014
PubMed

Different strategies are being tried to induce transplant tolerance in clinical settings; however, none of them are both safe and effective. Mesenchymal stem cells have been found to be potent immunomodulators and immunosuppressants. We discuss in this review different sources of mesenchymal stem cells and the potent role of adipose tissue-derived mesenchymal stem cells in induction of transplant tolerance including when to use them and how to use them for achieving the Utopian dream of transplant tolerance.

Keywords:
immune suppressionimmunologyimmunopathologystem celltransplantation

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