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Related Experiment Video

Updated: May 1, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Ia diastolic dysfunction: an echocardiographic grade.

Anil Pandit1, Farouk Mookadam, Fayaz A Hakim

  • 1Department of Cardiovascular Diseases, Mayo Clinic, Scottsdale, Arizona.

Echocardiography (Mount Kisco, N.Y.)
|April 5, 2014
PubMed
Summary
This summary is machine-generated.

A new Grade Ia diastolic dysfunction group is proposed for patients with relaxation abnormalities and elevated filling pressures. This distinct group does not fit current echocardiographic grading standards.

Keywords:
diastolic dysfunctiondiastolic heart failurediastologyfilling pressuresleft atrial volume index

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Area of Science:

  • Cardiology
  • Echocardiography
  • Diastolic Function

Background:

  • Current echocardiographic grading of diastolic dysfunction may not encompass all patient profiles.
  • A need exists to identify distinct patient groups with diastolic dysfunction.

Purpose of the Study:

  • To demonstrate the existence of a distinct patient group with Grade Ia diastolic dysfunction.
  • To differentiate this group from existing Grades I and II diastolic dysfunction.

Main Methods:

  • Retrospective analysis of echocardiographic and demographic data from 515 patients.
  • Comparison of measurements including left atrial volume index, isovolumic relaxation time, and deceleration time between groups.
  • Statistical analysis adjusted for age, gender, diabetes, and smoking.

Main Results:

  • Grade Ia patients exhibited significantly different left atrial volume index, isovolumic relaxation time, and deceleration time compared to Grades I and II.
  • Medial and lateral E/e' values were significantly elevated in Grade Ia patients.
  • These differences remained significant after adjusting for confounding factors.

Conclusions:

  • Patients with relaxation abnormality (E/A ratio <0.8) and elevated filling pressures (septal E/e' ≥15, lateral E/e' ≥12, average E/e' ≥13) represent a distinct group.
  • This group should be classified as a separate Grade Ia diastolic dysfunction.
  • This refined grading may improve diagnostic accuracy and patient management.