Related Experiment Video
Updated: May 1, 2026
09:59
A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
16.7K
Predicting outcomes after transient ischemic attack and stroke
Continuum (Minneapolis, Minn.)
|April 5, 2014
Summary
Neurologists use prediction scores to assess outcomes after ischemic stroke. While new scores exist for mortality and thrombolysis complications, their clinical use requires further validation.
Area of Science:
- Neurology
- Clinical Prediction Models
Background:
- Predicting functional outcome and mortality post-stroke is crucial for neurologists.
- This review focuses on predictors of outcome specifically after ischemic stroke.
Purpose of the Study:
- To review existing and newly developed prediction scores for ischemic stroke outcomes.
- To evaluate the applicability of these scores in clinical practice.
Main Methods:
- Systematic review of literature on stroke outcome prediction.
- Analysis of recently developed prediction instruments.
Main Results:
- Several scores predict mortality, functional outcome, and risk of symptomatic intracranial hemorrhage (sICH) after thrombolysis.
- Ongoing validation studies are essential for assessing the general applicability of these scores.
- Prediction scores for stroke risk following TIA have also been developed.
Conclusions:
- Current prediction scores for stroke mortality and outcome may be premature for individual patient determination.
- These scores should not be used to withhold tissue plasminogen activator (tPA) therapy, even with predicted high risk of sICH or poor outcome.
Related Concept Videos
01:26Transient Ischemic Attack l: Introduction
18
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
18
01:15Ischemic Stroke ll: Pathophysiology
54
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54
01:15Ischemic Stroke l: Introduction
44
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
44