Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

119
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
119
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infection Burden in Mismatched Unrelated Donor Hematopoietic Cell Transplantation: Results from the ACCESS Trial.

Blood advances·2026
Same author

Infections Within 100 Days of Idecabtagene Vicleucel and Impact on Survival for Relapsed/Refractory Multiple Myeloma: A CIBMTR Analysis.

Transplantation and cellular therapy·2026
Same author

The tissue-specific regulation of immunobiology by IL-17 signaling.

Science immunology·2026
Same author

An IL-1, IL-17, and IL-22 cytokine circuit controls vulvovaginal candidiasis independently of estrogen.

PLoS pathogens·2026
Same author

An IL-17-DUOX2 axis controls gastrointestinal colonization by Candida albicans.

Nature communications·2026
Same author

Non-canonical IL‑22 receptor signaling remodels the oral mucosal barrier during Candida albicans immunosurveillance.

Nature communications·2026

Related Experiment Video

Updated: May 1, 2026

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis
07:57

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

Published on: December 8, 2011

33.2K

Animal models for candidiasis.

Heather R Conti1, Anna R Huppler2, Natasha Whibley1

  • 1Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

Current Protocols in Immunology
|April 5, 2014
PubMed
Summary

This study details established mouse models for studying Candida albicans infections, including disseminated, oropharyngeal, vaginal, and cutaneous candidiasis. It provides methods for Candida albicans growth and detection, crucial for understanding these common human fungal infections.

Keywords:
Candida albicansfungal infectionmouse model

More Related Videos

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
06:39

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

1.6K
The Galleria mellonella Waxworm Infection Model for Disseminated Candidiasis
07:33

The Galleria mellonella Waxworm Infection Model for Disseminated Candidiasis

Published on: November 17, 2018

11.0K

Related Experiment Videos

Last Updated: May 1, 2026

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis
07:57

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

Published on: December 8, 2011

33.2K
Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
06:39

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

1.6K
The Galleria mellonella Waxworm Infection Model for Disseminated Candidiasis
07:33

The Galleria mellonella Waxworm Infection Model for Disseminated Candidiasis

Published on: November 17, 2018

11.0K

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Animal Models

Background:

  • Candidiasis, a fungal infection caused by Candida species, presents significant clinical importance in humans.
  • Various forms of candidiasis, including disseminated, oropharyngeal, vaginal, and cutaneous infections, affect patient health.
  • Standardized experimental models are essential for investigating Candida pathogenesis and evaluating antifungal strategies.

Purpose of the Study:

  • To describe established murine models for key forms of candidiasis.
  • To provide detailed methodologies for the cultivation and detection of Candida albicans.
  • To facilitate research into Candida albicans infections using reliable animal models.

Main Methods:

  • Development and validation of disseminated candidiasis models in mice.
  • Establishment of oropharyngeal candidiasis models in murine subjects.
  • Creation of vaginal and cutaneous candidiasis models for experimental use.
  • Standardized protocols for Candida albicans culture and quantitative detection.

Main Results:

  • Successfully established and characterized murine models for disseminated, oropharyngeal, vaginal, and cutaneous candidiasis.
  • Detailed protocols for consistent Candida albicans growth and accurate detection are provided.
  • The described models allow for reproducible investigation of fungal infection dynamics.

Conclusions:

  • The described murine models offer robust platforms for candidiasis research.
  • Standardized methods for Candida albicans handling are crucial for experimental consistency.
  • These resources support the advancement of understanding and treating human candidiasis.