Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Replisome03:01

The Replisome

31.2K
DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
31.2K
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

2.1K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
2.1K
Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

1.7K
Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
1.7K
Nucleic Acid Structure01:25

Nucleic Acid Structure

8.1K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
8.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Binary colloidal mixtures in near-critical binary solvents.

The Journal of chemical physics·2026
Same author

Spermine is an endogenous iron chelator that inhibits ferroptosis.

Nature·2026
Same author

Ferroptosis inhibition enhances liver and lung graft function.

Cell·2026
Same author

Urinary tract infections after benign cystectomy: Incidence, risk factors, pathogens, and resistance patterns.

Investigative and clinical urology·2026
Same author

The atomic structure of human dystrophin spectrin-like repeat 24.

Acta crystallographica. Section F, Structural biology communications·2026
Same author

Using test particle sum rules to improve approximations in classical density functional theory: White-Bear and White-Bear mark II versions of the Lutsko functional.

Physical review. E·2026

Related Experiment Video

Updated: May 1, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K

Modular construction of dynamic nucleodendrimers.

Valentina Abet1, Robert Evans, Florian Guibbal

  • 1Centre de Recherche de Gif, Institut de Chimie des Substance Naturelles du CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette (France) http://rodchembiolab.com.

Angewandte Chemie (International Ed. in English)
|April 5, 2014
PubMed
Summary

Small molecules containing isoguanosine self-assemble into decameric nucleodendrimers. Alkali metals, particularly cesium, promote stable decameric assemblies, while guanosine derivatives facilitate formation without direct incorporation.

Keywords:
NMR spectroscopycesiumdendrimersisoguanosineself-assembly

More Related Videos

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

6.7K
Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

1.5K

Related Experiment Videos

Last Updated: May 1, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

6.7K
Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

1.5K

Area of Science:

  • Supramolecular Chemistry
  • Dendrimer Synthesis
  • Nucleoside Chemistry

Background:

  • Dendrimers are highly branched macromolecules with diverse applications.
  • Self-assembly offers a modular approach to constructing complex molecular architectures.
  • Nucleoside analogs can introduce unique properties into dendritic structures.

Purpose of the Study:

  • To investigate the self-assembly of isoguanosine-containing small molecules into nucleodendrimers.
  • To explore the influence of solvents and alkali metal ions on assembly formation.
  • To understand the role of guanosine derivatives in the self-assembly process.

Main Methods:

  • 1D NMR spectroscopy
  • 2D DOSY NMR spectroscopy
  • Mass spectrometry

Main Results:

  • Isoguanosine-based building blocks self-assemble into decameric nucleodendrimers.
  • Apolar building blocks form pentameric structures in acetonitrile.
  • Alkali metal ions, especially cesium, stabilize decameric assemblies.
  • Guanosine derivatives promote decamer formation without being incorporated, mimicking molecular crowding.

Conclusions:

  • A facile and modular method for creating polyfunctional dendritic macromolecules using isoguanosine building blocks has been developed.
  • The self-assembly process is tunable by solvent choice and the presence of specific alkali metal ions.
  • The observed phenomenon offers insights into biomolecular assembly mechanisms like molecular crowding.