Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

8.4K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
8.4K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

1.2K
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1.2K
Nephrons01:10

Nephrons

8.2K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
8.2K
Diabetic Nephropathy01:28

Diabetic Nephropathy

32
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
32
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

409
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
409
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

1.4K
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease.

Kidney international·2026
Same author

Shared multicellular injury programs of acute and chronic kidney disease enable mechanistic patient stratification.

medRxiv : the preprint server for health sciences·2026
Same author

The podocyte slit-diaphragm: target of anti-nephrin antibodies.

Current opinion in nephrology and hypertension·2026
Same author

Urinary clusterin as a biomarker of human kidney disease progression and response to the endothelin receptor antagonist atrasentan: An exploratory analysis from the SONAR trial.

Nature communications·2026
Same author

Case Series of Histopathological Findings in Chronic Kidney Disease: Insights From the Kidney Precision Medicine Project.

Kidney medicine·2026
Same author

Rapid podocyte loss in murine models triggers the formation of podocyte-parietal epithelial cell intercellular bridges.

American journal of physiology. Renal physiology·2026
Same journal

A Patient's Perspective on Arteriovenous Fistula Care and Far-Infrared Radiation Arteriovenous Fistula Therapy.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same journal

A Beacon of Hope: Pegcetacoplan for Adolescents with C3 Glomerulopathy or Primary Immune Complex Membranoproliferative GN.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same journal

Sequential Biomarker Testing in Kidney Transplant Surveillance: How Far Does One Step at a Time Take Us?

Clinical journal of the American Society of Nephrology : CJASN·2026
Same journal

The Predicting Risk of Cardiovascular Disease Event Equation Meets CKD.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same journal

Muscle Cramp Rate, Severity and Burden in Maintenance Hemodialysis Patients: A Yearlong Multicenter Quality Improvement Initiative.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same journal

From Risk Determinants to Clinical Action: Understanding and Implementing the Cardiovascular Kidney Metabolic Syndrome Framework.

Clinical journal of the American Society of Nephrology : CJASN·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.7K

Glomerular disease: looking beyond pathology.

Roger C Wiggins1, Charles E Alpers1, Lawrence B Holzman1

  • 1Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.

Clinical Journal of the American Society of Nephrology : CJASN
|April 5, 2014
PubMed
Summary
This summary is machine-generated.

Scientists identified key research priorities for glomerular disease, focusing on new diagnostics and treatments. This dialogue aims to improve kidney function understanding and patient outcomes through targeted research and better clinical trial participation.

Keywords:
GNautoantibodiesendotheliumglomerulosclerosisinflammationnephrotic syndromepodocytestranslational and clinical research

More Related Videos

Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

21.0K
Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

8.7K

Related Experiment Videos

Last Updated: May 1, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.7K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

21.0K
Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

8.7K

Area of Science:

  • Nephrology
  • Glomerular Diseases
  • Kidney Research

Background:

  • The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) initiated a national dialogue to gather research priorities for kidney disease.
  • Over 1600 participants contributed nearly 300 ideas over two years, covering diverse aspects of kidney disease.

Purpose of the Study:

  • To formulate and prioritize research objectives for a better understanding of kidney function and disease progression.
  • To shift focus from pathology to leveraging basic and clinical research for improved diagnostic classification and therapies in primary glomerular disease.

Main Methods:

  • A national dialogue involving 1600 scientific participants.
  • Analysis of nearly 300 submitted research ideas across all kidney disease areas.
  • Identification of overarching themes and high-priority research areas.

Main Results:

  • A consensus emerged on prioritizing research beyond pathology for glomerular diseases.
  • High-priority areas include therapeutic targets (endothelium, podocytes), podocyte regeneration, longitudinal cohorts for classification, biomarkers, disease-specific therapeutics, autoantibody triggers, and clinical trial culture.
  • These objectives offer a roadmap for advancing glomerular disease research.

Conclusions:

  • The identified research objectives provide a clear path forward for improving clinical outcomes in glomerular disease.
  • Focusing on specific targets, patient cohorts, and biomarkers is crucial for therapeutic advancements.
  • Enhancing clinical research culture is essential for accelerating progress in kidney disease treatment.