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Cognitive mapping deficits in schizophrenia: a critical overview.
Anushree Bose1, Sri Mahavir Agarwal1, Sunil V Kalmady1
1Department of Psychiatry, The Schizophrenia Clinic, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India ; Department of Psychiatry, Translational Psychiatry Laboratory, Cognitive Neurobiology Division, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Schizophrenia is linked to hippocampal deficits and impaired cognitive mapping. This review highlights how these spatial processing issues may explain cognitive and positive symptoms in schizophrenia.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Psychiatry
Background:
- Hippocampal deficits are a known feature of schizophrenia.
- Schizophrenia is increasingly associated with allocentric (spatial) processing deficits.
Purpose of the Study:
- To review evidence linking cognitive mapping deficits to schizophrenia.
- To explore the role of hippocampal function in schizophrenia's cognitive aberrations.
Main Methods:
- Review of existing literature on hippocampal function and schizophrenia.
- Analysis of cognitive mapping theory (O'Keefe & Nadel, 1978) in relation to schizophrenia.
Main Results:
- Emerging evidence suggests cognitive mapping deficits are significant in schizophrenia.
- Hippocampally-mediated allocentric processing deficits correlate with spatial/representational deficits and positive symptoms.
Conclusions:
- Evidence supports cognitive mapping theory in explaining certain schizophrenia deficits.
- Cognitive mapping deficits may serve as a promising endophenotype or biomarker for schizophrenia.
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