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Updated: May 1, 2026

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
Published on: January 9, 2026
Invadopodia formation in blood clots: Not so SLUGgish after all
Lynn M Knowles1, Jodi K Maranchie2, Jan Pilch2
1Department of Urology; University of Pittsburgh School of Medicine; Shadyside Medical Center; Pittsburgh, PA USA.
Abstract:
Blood clotting specifically supports the metastatic dissemination of malignant cells to the lung. We have recently demonstrated that 2 tumor types that are prone to form lung metastases, renal cell carcinoma and soft tissue sarcoma, share specific adhesive mechanisms that support the invasion and colonization of blood clots in the pulmonary vasculature.
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