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Updated: May 1, 2026

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
Published on: October 30, 2016
A novel pathway links telomeres to NK-cell activity: Implications for immunotherapy
Julien Cherfils-Vicini1, Pasquale Zizza2, Eric Gilson3
1Institut for Research on Cancer and Aging; Nice (IRCAN); CNRS UMR7284/INSERM U1081; Faculty of Medicine; Nice University; Nice, France.
Abstract:
Here, we describe a model in which telomeric repeat-binding factor 2 (TERF2) can control tumorigenesis not only via cancer cell-intrinsic mechanisms but also via non-cancer cell autonomous pathways. Indeed, we have recently shown that TERF2 regulates tissue homeostasis as it promotes the elimination of aged, damaged, and neoplastic cells by the immune system, opening the way to new therapeutic options against cancer.
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