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Updated: May 1, 2026

Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
The anticancer effects of HDAC inhibitors require the immune system
Alison C West1, Mark J Smyth2, Ricky W Johnstone3
1Cancer Therapeutics Program; The Peter MacCallum Cancer Centre; East Melbourne, VIC Australia ; Cancer Immunology Programs; The Peter MacCallum Cancer Centre; East Melbourne, VIC Australia.
Abstract:
Histone deacetylase inhibitors (HDACis) are known to exert immunomodulatory effects. We have recently demonstrated that the therapeutic efficacy of HDACis against aggressive B-cell lymphoma and colon carcinoma relies on a functional immune system, in particular on the production of interferon γ (IFNγ). Our findings provide a rationale for the combination of HDACis with immunotherapeutic agents in the clinic.
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