Related Experiment Video

Updated: May 1, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

1.2K

Glycosylated Haemoglobin (HbA1c) - A Marker of Circulating Lipids in Type 2 Diabetic Patients

Prabhavathi K1, Kirthana Kunikullaya U2, Jaisri Goturu3

  • 1Assistant Professor, Department of Physiology, SRM Medical College, Hospital and Research centre , Kattankulathur, Chennai, Tamil Nadu, India .

Journal of Clinical and Diagnostic Research : JCDR
|April 5, 2014
PubMed

Insights

Glycosylated hemoglobin (HbA1c) can predict lipid levels in Type 2 diabetes patients. This finding helps identify individuals at high risk for cardiovascular disease, enabling early intervention for better health outcomes.

Area of Science:

  • Endocrinology
  • Clinical Biochemistry
  • Cardiovascular Medicine

Background:

  • Type 2 diabetes and dyslipidemia significantly increase cardiovascular disease (CVD) risk.
  • Early lipid normalization is crucial for reducing CVD morbidity and mortality.
  • Glycosylated hemoglobin (HbA1c) is a standard indicator of long-term glycemic control.

Purpose of the Study:

  • To evaluate if HbA1c can serve as a predictive marker for circulating lipid levels in Type 2 diabetic patients.
  • To explore the correlation between glycemic control and lipid profiles in this population.

Main Methods:

  • Analysis of sera from 130 Type 2 diabetic patients for fasting blood sugar (FBS), HbA1c, and lipid profiles (TC, TG, HDL, LDL).
  • Patients were stratified into three glycemic control groups based on HbA1c levels (<6%, 6-9%, >9%).
  • Statistical analysis included one-way ANOVA and post-hoc Dunnett's tests.

Main Results:

  • HbA1c levels were significantly higher in females than males.
  • No significant differences in HbA1c, FBS, or lipid profiles were observed between older and younger patients.
  • HbA1c demonstrated direct and significant correlations with total cholesterol, triglycerides, and LDL cholesterol.
  • Univariate analysis confirmed HbA1c as a reliable predictor of circulating lipid levels.

Conclusions:

  • HbA1c is a valuable marker for assessing lipid profiles in Type 2 diabetic patients.
  • Utilizing HbA1c can aid in screening diabetic individuals at elevated risk for cardiovascular diseases.
  • This approach supports timely interventions to mitigate cardiovascular complications.
Abstract

Keywords:
Coronary artery diseaseDyslipidemiaGlycemic control

More Related Videos

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

70.1K
Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique07:35

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique

Published on: January 26, 2024

2.1K

Related Concept Videos

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated...
17
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose...
25
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.9K
Hypoglycemia01:26

Hypoglycemia

Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...
30
Hyperosmolar Hyperglycemic State01:21

Hyperosmolar Hyperglycemic State

Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
20
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.5K