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Updated: May 1, 2026
10:49
Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
10.6K
[Ceftaroline breakpoints].
Andrés Canut1, Luis Martínez-Martínez2
1Servicio de Microbiología, Hospital Universitario de Álava, Vitoria, España.
Enfermedades Infecciosas Y Microbiologia Clinica
|April 8, 2014
Summary
Ceftaroline, a novel cephalosporin, shows potent activity against resistant bacteria like methicillin-resistant Staphylococcus aureus. Regulatory bodies have established clinical breakpoints to guide its effective use in treating infections.
Area of Science:
- Microbiology
- Pharmacology
- Clinical Science
Context:
- Ceftaroline is a new parenteral cephalosporin antibiotic.
- It exhibits significant in vitro activity against key pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).
- Its mechanism involves inhibiting penicillin-binding protein 2a, crucial for MRSA resistance.
Purpose:
- To summarize the microbiological properties and clinical relevance of ceftaroline.
- To outline the breakpoint definitions set by regulatory bodies for ceftaroline.
- To establish clinical categories for various bacterial pathogens based on ceftaroline's activity.
Summary:
- Ceftaroline demonstrates notable microbiological activity, particularly against MRSA by targeting PBP2a.
- The European Committee of Antimicrobial Susceptibility Testing (EUCAST) and the Clinical and Laboratory Standards Institute (CLSI) have defined epidemiological and clinical breakpoints for ceftaroline.
- Clinical categories for treating infections caused by enterobacteria, S. aureus, H. influenzae, S. pneumoniae, and beta-hemolytic Streptococcus have been established.
Impact:
- Provides a basis for the clinical application of ceftaroline in treating infections caused by susceptible pathogens.
- Facilitates standardized interpretation of susceptibility testing for ceftaroline.
- Contributes to antimicrobial stewardship by defining appropriate use criteria.
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