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Updated: May 1, 2026
07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
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Myxofibrosarcoma of the thyroid gland
Y Darouassi1, H Attifi1, M Zalagh1
1Service d'Oto-Rhino-Laryngologie, Hôpital Militaire d'Instruction Mohammed V, avenue des FAR Hay Riad, 10000 Rabat, Morocco.
Summary
Thyroid myxofibrosarcoma is extremely rare, presenting diagnostic and treatment challenges. Early MRI and histological diagnosis are crucial due to high recurrence risk and potential for grade worsening.
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Myxofibrosarcoma of the thyroid gland is an exceptionally rare malignancy.
- Literature review reveals only one previously reported case, highlighting its rarity.
Observation:
- A case of a 74-year-old female patient with left thyroid lobe swelling and ipsilateral cervical lymphadenopathy is presented.
- The patient underwent total thyroidectomy with cervical lymph-node dissection.
- Histopathological analysis confirmed myxofibrosarcoma.
Findings:
- The tumor exhibited rapid local recurrence post-surgery.
- Chemotherapy with doxorubicin and ifosfamide was initiated following recurrence.
- Head and neck myxofibrosarcoma carries a significant risk of local recurrence and potential for grade progression.
Implications:
- Accurate histological diagnosis is paramount for effective management.
- Magnetic Resonance Imaging (MRI) is essential for diagnosis and pre-treatment assessment.
- Regular MRI follow-up is critical to monitor for recurrence and tumor progression.
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