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Updated: May 1, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Juvenile generalized pustular psoriasis treated with etanercept
Jorga Fialová1, Nadežda Vojáčková, Daniela Vaňousová
1Deparment of Dermatovenereology, 2nd Medical Faculty, Charles University and Bulovka Hospital, Prague, Czech Republic.
Dermatologic Therapy
|April 8, 2014
Summary
Etanercept successfully treated a child with severe general pustular psoriasis (GPP) and Cushing syndrome when other therapies failed. This biologic offers a safe and effective option for refractory pediatric GPP.
Area of Science:
- Pediatric Dermatology
- Immunodermatology
- Pharmacology
Background:
- General pustular psoriasis (GPP) is a rare, severe pediatric skin condition with serious complications.
- Previous treatments like acitretin, methotrexate, and methylprednisolone were ineffective in this case.
- The patient also had iatrogenic secondary Cushing syndrome, complicating treatment options.
Observation:
- An 8-year-old boy with GPP and Cushing syndrome was treated with etanercept.
- Etanercept targets tumor necrosis factor-alpha (TNF-alpha), a key inflammatory mediator.
- This treatment was administered after failure of conventional therapies.
Findings:
- Etanercept demonstrated significant clinical response in the pediatric GPP patient.
- Long-term efficacy was observed without acute exacerbations.
- The treatment exhibited an excellent safety and tolerability profile.
Implications:
- Etanercept represents a viable therapeutic option for children with refractory GPP.
- This case highlights the potential of TNF-alpha inhibitors in managing severe pediatric psoriasis variants.
- Further research into biologics for pediatric GPP is warranted.
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