Related Experiment Video
Updated: May 1, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Diagnosis and clinical manifestations of calcium pyrophosphate and basic calcium phosphate crystal deposition
Hang-Korng Ea1, Frédéric Lioté1
1AP-HP, hôpital Lariboisière, Service de rhumatologie (centre Viggo Petersen), pôle appareil locomoteur, 2 Rue Ambroise Paré, Paris F-75010, France; Sorbonne Paris Cité, University Paris Diderot (UFR de Médecine), 10 Avenue de Verdun, Paris F-75205, France; INSERM, UMR-S 1132, Hopital Lariboisière, 2 Rue Ambroise Paré, Paris F-75010, France.
Abstract:
Basic calcium phosphate and pyrophosphate calcium crystals are the 2 main calcium-containing crystals that can deposit in all skeletal tissues. These calcium crystals give rise to numerous manifestations, including acute inflammatory attacks that can mimic alarming and threatening differential diagnoses, osteoarthritis-like lesions, destructive arthropathies, and calcific tendinitis. Awareness of uncommon localizations and manifestations such as intraspinal deposition (eg, crowned dens syndrome, tendinitis of longus colli muscle, massive cervical myelopathy compression) prevents inappropriate procedures and cares. Coupling plain radiography, ultrasonography, computed tomography, and synovial fluid analysis allow accurate diagnosis by directly or indirectly identifying the GRAAL of microcrystal-related symptoms.
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