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Long-term management of gout: nonpharmacologic and pharmacologic therapies
Yashaar Chaichian1, Saima Chohan1, Michael A Becker1
1Section of Rheumatology, The University of Chicago, 5841 South Maryland Avenue, MC 0930, Chicago, IL 60637, USA.
Abstract:
Gout is a common disorder with clinical signs and symptoms resulting from inflammatory responses to monosodium urate crystals deposited in tissues from extracellular fluids saturated for urate. Long-term management of gout focuses on nonpharmacologic and pharmacologic means to achieve and maintain serum urate levels in a subsaturating range. Despite a firm understanding of gout pathophysiology, means to achieve certain diagnosis, and a variety of effective therapies, treatment outcomes remain suboptimal. In this review, available nonpharmacologic and pharmacologic therapies for chronic gout are discussed and a framework is provided for successful achievement and maintenance of goal-range serum urate levels.
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