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Vibrational spectroscopy in stem cell characterisation: is there a niche?
J Sulé-Suso1, N R Forsyth2, V Untereiner3
1Cancer Centre, University Hospital of North Staffordshire, Newcastle Road, Stoke on Trent, Staffordshire, ST4 6QG, UK; Institute for Science and Technology in Medicine, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Stoke on Trent, ST4 7QB, UK.
Trends in Biotechnology
|April 8, 2014
Summary
Vibrational spectroscopy aids disease diagnosis and stem cell research. Further work is needed to translate these powerful techniques into clinical practice for tissue engineering.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
Background:
- Vibrational spectroscopy, including infrared and Raman, is increasingly used in clinical settings.
- Recent applications focus on stem cell differentiation and tissue analysis.
Purpose of the Study:
- To review the application of vibrational spectroscopy in disease diagnosis and stem cell research.
- To highlight potential clinical applications in tissue engineering and identify challenges for translation.
Main Methods:
- Infrared spectroscopy
- Raman spectroscopy
Main Results:
- Vibrational spectroscopy shows potential in characterizing stem cell differentiation phenotypes.
- These techniques can aid in disease diagnosis and assessing stem cell presence in tissues.
Conclusions:
- Vibrational spectroscopy holds promise for clinical applications, particularly in tissue engineering.
- Addressing current challenges is crucial for the successful clinical translation of these techniques.
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