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[Frontal fibrosing alopecia]
1Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France; Centre Sabouraud, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
Annales De Dermatologie Et De Venereologie
|April 8, 2014
Summary
Frontal fibrosing alopecia (FFA), a scarring hair loss condition, often affects eyebrows and body hair. Current treatments lack proven efficacy for this rare disorder.
Area of Science:
- Dermatology
- Trichology
Context:
- Frontal fibrosing alopecia (FFA) is a scarring alopecia characterized by band-like hair loss on the scalp's anterior area.
- FFA shares clinical and histological features with lichen planopilaris (LPP), often considered a variant.
- Associated symptoms include eyebrow, facial, and body hair loss.
Purpose:
- To review the proposed treatments for frontal fibrosing alopecia (FFA).
- To highlight the lack of definitive evidence for the efficacy of current therapeutic options.
Summary:
- FFA presents with a lymphocytic infiltrate and follicular destruction, leading to fibrosis.
- While typically affecting post-menopausal women, FFA also occurs in men and younger women.
- The pathophysiology of FFA remains unknown, and the condition progresses slowly with unpredictable stabilization.
Impact:
- This review provides a comprehensive overview of treatment strategies for FFA.
- It underscores the need for further research to establish effective therapies for this orphan disease.
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