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Updated: May 1, 2026
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
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Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids
1Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University, United States.
Chemistry and Physics of Lipids
|April 8, 2014
Summary
Oxidatively modified phospholipids (oxPL) are formed from phospholipids and act as signaling molecules. This review covers four major oxPL classes, their formation, biological roles, and elimination pathways.
Area of Science:
- Biochemistry
- Cell Biology
- Lipidomics
Background:
- Phospholipids are converted into oxidatively modified phospholipids (oxPL) through peroxidation.
- These oxPL function as critical signaling molecules in biological systems.
Purpose of the Study:
- To review four major classes of oxPL.
- To discuss their formation mechanisms, biological activities, and elimination pathways.
Main Methods:
- Literature review of oxPL formation and function.
- Analysis of signaling pathways and catabolic processes.
Main Results:
- Detailed examination of four oxPL classes: mildly oxygenated, truncated acyl chains, cyclized acyl chains, and N-modified headgroups.
- Evidence for oxPL formation in biological samples is presented.
Conclusions:
- OxPL play diverse roles in physiology and disease.
- Further research is needed to fully elucidate the functions of oxPL.
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