Related Experiment Video
Updated: May 1, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
14.4K
Non-coding RNAs in cerebral endothelial pathophysiology: emerging roles in stroke
Ke-Jie Yin1, Milton Hamblin2, Y Eugene Chen1
1Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
Neurochemistry International
|April 8, 2014
Summary
Non-coding RNAs (ncRNAs) are key regulators of brain endothelial cell function. Their dysregulation is linked to stroke pathology, with microRNAs (miRNAs) playing a critical role in the brain
Area of Science:
- Neuroscience
- Molecular Biology
- Vascular Biology
Background:
- Cerebral vascular endothelial cells are crucial for the blood-brain barrier (BBB).
- Cerebral ischemia causes BBB disruption, inflammation, and neurovascular remodeling.
- Endothelial dysfunction in stroke is regulated by complex gene signaling networks.
Purpose of the Study:
- To review the role of non-coding RNAs (ncRNAs) in cerebrovascular endothelium.
- To highlight the specific functions of endothelial microRNAs (miRNAs) in stroke.
Main Methods:
- Literature review of ncRNAs in brain vasculature.
- Focus on endothelial miRNAs and their regulatory mechanisms.
Main Results:
- ncRNAs, including miRNAs, lncRNAs, snoRNAs, and piRNAs, are highly expressed in cerebral endothelium.
- Dysregulation of ncRNAs is implicated in cerebrovascular endothelial pathophysiology and neurological disorders.
- Endothelial miRNAs are critical mediators in the response to ischemic stimuli.
Conclusions:
- ncRNAs are vital for maintaining normal cerebral vascular function.
- Aberrant ncRNA activity contributes to stroke-related brain injury.
- Endothelial miRNAs represent a significant area of research for stroke treatment.
Keywords:
AngiogenesisBlood–brain barrierCerebral vascular endothelial cellsIschemic strokeNon-coding RNAsmicroRNAMore Related Videos
Related Concept Videos
01:15Ischemic Stroke ll: Pathophysiology
54
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54
01:29Hemorrhagic Stroke ll: Pathophysiology
30
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
30
01:15Ischemic Stroke l: Introduction
44
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
44
01:22Cerebral Edema ll: Pathophysiology
19
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
19
01:29Stroke: Introduction and Types
55
A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
55
01:17Hemorrhagic Stroke l: Introduction
20
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
20