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Dose calibrator manufacturer-dependent bias in assays of ¹²³I
Denis E Bergeron1, Jeffrey T Cessna1, Daniel B Golas1
1Physical Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Stop 8462, Gaithersburg, MD 20899-8462, USA.
Abstract:
Calibration factors for commercial ionization chambers (i.e. dose calibrators) were determined for a solution of (123)I; the activity was based on the 1976 NBS standard. A link between the NIST standard and the International Reference System (SIR) was established. The two major U.S. dose calibrator manufacturers recommend oppositely biased calibration factors, giving a spread of 11.3% in measured activities. With modern quantitative imaging techniques capable of ≤10% accuracy, this bias for a SPECT nuclide is highly significant.
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