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Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

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The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
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Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

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Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
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Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Related Experiment Video

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Isolation of Primary Myofibroblasts from Mouse and Human Colon Tissue
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Abdominal inflammatory myofibroblastic tumor.

Roosmarijn L Groenveld1, Menno H Raber1, Richard Oosterhof-Berktas2

  • 1Department of Surgery, Laboratorium Pathologie Oost Nederland, Hengelo, The Netherlands.

Case Reports in Gastroenterology
|April 8, 2014
PubMed
Summary

A rare benign tumor, inflammatory myofibroblastic tumor (IMT), was diagnosed in a 28-year-old woman presenting with abdominal pain. Complete surgical resection was performed, confirming IMT and highlighting the importance of radical surgery for abdominal IMT.

Keywords:
Abdominal inflammatory myofibroblastic tumorInflammatory myofibroblastic tumorInflammatory pseudotumorLaparotomy

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Area of Science:

  • Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Inflammatory myofibroblastic tumor (IMT) is a rare benign neoplasm with nonspecific symptoms.
  • Abdominal IMT requires radical surgery due to high local recurrence rates.

Observation:

  • A 28-year-old woman presented with abdominal pain, weight loss, and a palpable intra-abdominal mass.
  • CT scan revealed a 7 cm tumor with sharp margins, intra-tumoral fat, and enhancing soft tissue.
  • Initial workup suggested IMT, leading to surgical exploration.

Findings:

  • Pathological examination confirmed the diagnosis of inflammatory myofibroblastic tumor (IMT).
  • The tumor was completely resected via laparotomy.

Implications:

  • This case highlights the clinical, radiological, and histological features of abdominal IMT.
  • Emphasizes the necessity of complete surgical resection for managing abdominal IMT to prevent recurrence.