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Updated: May 1, 2026
Laser-assisted Lentiviral Gene Delivery to Mouse Fertilized Eggs
Published on: November 1, 2018
A study comparing three different laser-assisted hatching techniques
Purpose Of Investigation:
Laser-assisted hatching (LAH) is recognized as a useful technology to improve clinical pregnancy rates and implantation rates. This study reports the differences between a new LAH method and two conventional LAH techniques.
Materials And Methods:
The authors studied 151 patients with repeated implantation failure, who were divided into three groups.
Results:
In group 1, the zona pellucida (ZP) was opened using LAH (n = 52). In group 2, laser-assisted thinning was performed to dissolve the outer layer of the ZP (n = 49). In group 3, laser-assisted thinning was performed to dissolve the inner layer of the ZP (n = 50). The clinical pregnancy rates and implantation rates among the groups were compared. The results demonstrate that there are significant differences in the clinical pregnancy rates and implantation rates between group 3 and the other two groups.
Conclusion:
Performing laser-assisted thinning to dissolve the inner layer of the ZP markedly increases the pregnancy rates and implantation rates of patients with repeated implantation failure.
