Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters01:16

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

189
The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
189
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

81
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
81
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

159
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
159
Multiple Comparison Tests01:13

Multiple Comparison Tests

3.4K
Multiple comparison test, abbreviated as MCT, is a post hoc analysis generally performed after comparing multiple samples with one or more tests. An MCT will help identify a significantly different sample among multiple samples or a factor among multiple factors.
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multimodal and retro-mode imaging in sclerochoroidal calcification: A case report.

Archivos de la Sociedad Espanola de Oftalmologia·2024
Same author

Retro-mode imaging for the diagnosis of optic disc drusen: a case series.

Archivos de la Sociedad Espanola de Oftalmologia·2024
Same author

Pedi-R-MAPP: The development of a nutritional awareness tool for use in remote paediatric consultations using a modified Delphi consensus.

Clinical nutrition (Edinburgh, Scotland)·2022
Same author

Allogeneic hematopoietic stem cell transplantation for patients with relapsed/refractory systemic anaplastic large cell lymphoma. A retrospective analysis of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation.

Bone marrow transplantation·2019
Same author

Effectiveness of rotavirus pentavalent vaccine under a universal immunization programme in Israel, 2011-2015: a case-control study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2017
Same author

Heteroclinic dynamics of coupled semiconductor lasers with optoelectronic feedback.

Optics letters·2016

Related Experiment Video

Updated: May 1, 2026

A Rapidly Incremented Tethered-Swimming Maximal Protocol for Cardiorespiratory Assessment of Swimmers
09:24

A Rapidly Incremented Tethered-Swimming Maximal Protocol for Cardiorespiratory Assessment of Swimmers

Published on: January 28, 2020

7.8K

Differences in MCT1 A1470T polymorphism prevalence between runners and swimmers.

S Ben-Zaken1, A Eliakim2, D Nemet2

  • 1Genetics and Molecular Biology Laboratory, The Zinman College of Physical Education and Sports Sciences at the Wingate Institute, Netanya, Israel.

Scandinavian Journal of Medicine & Science in Sports
|April 9, 2014
PubMed
Summary

The A1470T polymorphism in the monocarboxylate transporter 1 (MCT1) gene affects lactate transport. This study found a higher T-allele frequency in swimmers compared to runners, suggesting a potential link to swimming performance.

Keywords:
MCT1 polymorphismlactate transportrunnersswimmers

More Related Videos

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
04:45

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice

Published on: May 5, 2022

2.5K
Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

6.8K

Related Experiment Videos

Last Updated: May 1, 2026

A Rapidly Incremented Tethered-Swimming Maximal Protocol for Cardiorespiratory Assessment of Swimmers
09:24

A Rapidly Incremented Tethered-Swimming Maximal Protocol for Cardiorespiratory Assessment of Swimmers

Published on: January 28, 2020

7.8K
Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
04:45

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice

Published on: May 5, 2022

2.5K
Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

6.8K

Area of Science:

  • Exercise Physiology
  • Human Genetics
  • Sports Science

Background:

  • Skeletal muscle is a key site for lactate metabolism.
  • Lactate transport across cell membranes is crucial and mediated by the monocarboxylate transporter 1 (MCT1).
  • The MCT1 A1470T gene polymorphism (rs1049434) impacts lactate transport rates and blood lactate levels.

Purpose of the Study:

  • To investigate the allelic and genotype frequencies of the MCT1 A1470T polymorphism.
  • To compare these frequencies among Israeli track-and-field athletes, swimmers, and non-athletes.
  • To explore potential associations between the polymorphism and athletic performance in different disciplines.

Main Methods:

  • Genomic DNA was extracted from 173 track-and-field athletes, 80 swimmers, and 128 non-athletes.
  • Polymerase chain reaction (PCR) was used for genotyping the MCT1 A1470T polymorphism.
  • Athletes were subcategorized into runners (long-distance, middle-distance, power) and swimmers (long-distance, short-distance).

Main Results:

  • The T-allele frequency was significantly higher in long-distance swimmers (45%) compared to long- (27%) and middle-distance runners (30%).
  • Short-distance swimmers also showed a significantly higher T-allele frequency (40%) compared to power event athletes (25%).
  • Overall, swimmers (42%) exhibited a significantly higher T-allele frequency than runners (27%).

Conclusions:

  • The MCT1 A1470T polymorphism shows differential allelic frequencies between swimmers and runners.
  • A higher T-allele frequency is associated with swimmers across different distances and compared to various running disciplines.
  • Further research is warranted to determine if this polymorphism confers an advantage in swimming performance.