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[Thyroid function in patients with ventricular arrhythmia].

L N Vanin, A S Smetnev, S F Sokolov

    Kardiologiia
    |February 1, 1989
    PubMed
    Summary
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    Thyroid dysfunction, including hyperthyroidism and latent hypothyroidism, was common in patients with persistent ventricular arrhythmias. Treating hypothyroidism improved arrhythmia control and restored sensitivity to antiarrhythmic drugs.

    Area of Science:

    • Cardiology
    • Endocrinology
    • Internal Medicine

    Context:

    • Persistent ventricular arrhythmias pose a significant clinical challenge, often exhibiting resistance to standard antiarrhythmic therapies.
    • Thyroid dysfunction is a recognized comorbidity that can influence cardiovascular function.

    Purpose:

    • To investigate the prevalence of thyroid dysfunction in patients with persistent ventricular arrhythmias.
    • To assess the impact of thyroid dysfunction on the management and treatment response of ventricular arrhythmias.

    Summary:

    • A study of 21 patients with persistent ventricular arrhythmias (grades 2-5) found hyperthyroidism in 4.8% and latent hypothyroidism in 38.1% using radioimmune assays and thyroliberin (TRH) tests.
    • Thyroid dysfunction was a key factor contributing to resistance to antiarrhythmic treatment in most patients.

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  • Latent thyroid dysfunction was more prevalent in elderly patients with ventricular arrhythmias, especially those with a history of thyroid issues or abnormal thyroid scans.

    • Impact:

    • Treatment of hypothyroidism with substitution therapy led to the resolution of ventricular tachycardia episodes and reduced the frequency and severity of ventricular extrasystoles.
    • Restoration of thyroid function normalized patient sensitivity to antiarrhythmic medications, overcoming prior treatment resistance.