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Low testosterone is associated with disability in men with multiple sclerosis.

R Bove1, A Musallam2, B C Healy3

  • 1Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Brookline, MA, USAHarvard Medical School, Boston, MA, USACenter for Neurologic Diseases, Harvard Medical School, Boston, MA, USA.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|April 9, 2014
PubMed
Summary

Hypogonadism is common in men with multiple sclerosis (MS). Low testosterone levels correlate with worse disability and cognitive decline, suggesting a potential neuroprotective role for testosterone.

Keywords:
Body mass indexcognitioncognitive impairmentdisabilityhormoneshypogonadismleptinmultiple sclerosistestosterone

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Area of Science:

  • Neurology
  • Endocrinology
  • Immunology

Background:

  • Gonadal steroids, such as testosterone, may influence the progression of multiple sclerosis (MS).
  • Hypogonadism, a condition of low sex hormone production, is being investigated for its role in MS.
  • Understanding hormonal influences is crucial for managing MS in men.

Purpose of the Study:

  • To determine the prevalence of hypogonadism in men diagnosed with MS.
  • To explore the relationship between hypogonadism and clinical indicators of MS severity.
  • To investigate potential associations between testosterone levels and disease progression.

Main Methods:

  • A cohort of 96 male patients with relapsing-remitting MS (RRMS) or clinically-isolated syndrome (CIS) were analyzed.
  • Hormone levels, including total testosterone, were measured from stored blood samples.
  • Clinical data, such as Expanded Disability Status Scale (EDSS) and Symbol Digit Modalities Test (SDMT) scores, were collected longitudinally.

Main Results:

  • 39% of men with MS exhibited hypogonadism (total testosterone < 288 ng/dL).
  • Low testosterone levels were negatively correlated with body mass index (BMI) and leptin.
  • Lower baseline testosterone levels were associated with increased disability (EDSS) and faster cognitive decline (SDMT).

Conclusions:

  • Hypogonadotropic hypogonadism may affect men with MS.
  • Low testosterone levels in men with MS are linked to poorer clinical outcomes.
  • Testosterone's potential neuroprotective effects in MS warrant further research.