Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Enhancing conventional biopsies: ultrasound-guided percutaneous bone marrow biopsy and aspiration.

Journal of ultrasound·2026

Same author

CT Features of Gastric Dilatation-Volvulus in Guinea Pigs.

Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·2026

Same author

Prospective Evaluation of Serial Biomarkers in Patients With Intermediate High Risk Acute Pulmonary Embolism: A Single Center Proof-of-Concept Study.

Pulmonary circulation·2026

Same author

Estimating the Causal Effect of Realistic Treatment Strategies Using Longitudinal Observational Data.

Medical decision making : an international journal of the Society for Medical Decision Making·2025

Same author

Feasibility of MR-Guided PET Reconstruction in Detection of Focal Cortical Dysplasia.

AJNR. American journal of neuroradiology·2025

Same author

Bulk-Rashba Effect with Suppressed Spin Relaxation in a Polar Phase of Bi<sub>1-</sub> <sub>x</sub>In<sub>1+</sub> <sub>x</sub>O<sub>3</sub>.

Advanced materials (Deerfield Beach, Fla.)·2025

Same journal

Differentiation of cortical areas: effects of free energy minimization with broken symmetry.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

Prior exposure to speech rapidly modulates cortical processing of high-level linguistic structure.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

Beta bursts in SMA mediate anticipatory muscle inhibition.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

Cognitive load modulates the effects of social contexts on facial expression processing.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

The neural mechanisms of aligning spatial perspectives.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

Relationships between bilateral tapping skills and brain gray matter volumes: a voxel-based morphometry study.

Cerebral cortex (New York, N.Y. : 1991)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 1, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Connectome and Maturation Profiles of the Developing Mouse Brain Using Diffusion Tensor Imaging.

Madhura Ingalhalikar¹, Drew Parker¹, Yasser Ghanbari¹

¹Section of Biomedical Image Analysis, Department of Radiology.

Cerebral Cortex (New York, N.Y. : 1991)

|April 9, 2014

Summary

This summary is machine-generated.

This study maps the developing mouse brain

Keywords:

connectome diffusion tensor imaging maturation mouse

More Related Videos

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Related Experiment Videos

Last Updated: May 1, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Area of Science:

Neuroscience
Computational Biology
Biophysics

Background:

Establishing a comprehensive structural connectome for the mouse brain is crucial for understanding neural network development and function.
Diffusion tensor magnetic resonance imaging (dMRI) and advanced connectivity analysis tools are key to mapping brain structure.
Imaging-based connectomics offers a powerful approach to study brain changes across development and in response to genetic factors.

Purpose of the Study:

To establish a structural mouse connectome using dMRI and connectivity analysis.
To present a connectomic trajectory of brain maturation in C57BL/6J mice from postnatal days 2-80.
To investigate age-related changes in both global and regional brain network features.

Main Methods:

Utilized diffusion tensor magnetic resonance imaging (dMRI) for data acquisition.
Applied advanced connectivity analysis tools to establish a whole-brain structural connectome.
Analyzed global network measures (density, global efficiency, modularity) and regional network metrics (degree, local efficiency).

Main Results:

Global network measures showed a nonlinear relationship with age.
Regional network metrics exhibited differential changes in subcortical (thalamus, hippocampus) and cortical (visual, motor cortex) regions.
A derived 'brain connectivity index' highly correlated (r = 0.95) with chronological age.

Conclusions:

Brain connectivity serves as a reliable marker for normal age progression in mice.
The established mouse connectome is valuable for detecting subtle deviations caused by genetic, environmental, or pharmacological factors.
This work provides a foundation for imaging-based structural connectomics in the mouse brain.