Membrane-bound KIT ligand-targeting DNA vaccination inhibits mammary tumor growth
Patrizia Dentelli1, Federica Cavallo2, Maria Felice Brizzi1
1Department of Medical Sciences; University of Torino; Torino, Italy.
Oncoimmunology
|April 9, 2014
Abstract:
We have recently demonstrated that a DNA vaccine targeting membrane-bound KIT ligand (KITL) inhibits tumor growth by interfering with vessel stabilization/permeability and by disrupting the recruitment of inflammatory cells and regulatory T cells, the latter being an essential mechanism by which tumors resist available treatments. Combining KITL-targeting vaccines with conventional chemotherapy might avert drug resistance and improve the efficacy of standard-of-care therapeutic interventions.
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