Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spermatogenesis01:41

Spermatogenesis

91.0K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
91.0K
Spermatogenesis01:22

Spermatogenesis

8.3K
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
8.3K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

7.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
7.5K
Ribosome Profiling02:24

Ribosome Profiling

3.2K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.2K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

6.0K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models.

Cell·2026
Same author

Protein synthesis during mouse spermatogenesis.

Current topics in developmental biology·2026
Same author

Unraveling spermatogenesis: A single-cell genomics perspective.

Current topics in developmental biology·2026
Same author

Nucleolar migration regulates meiotic sex chromosome inactivation via phase separation during mammalian spermatogenesis.

Nature communications·2026
Same author

MAP2K6 directly phosphorylates BCL2L13 to mediate mitophagy for suppressing tumorigenicity.

Cell reports·2026
Same author

Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models.

Cell·2026

Related Experiment Video

Updated: May 1, 2026

Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye
08:21

Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye

Published on: January 14, 2021

5.2K

Long noncoding RNAs in spermatogenesis: insights from recent high-throughput transcriptome studies.

Alfred Chun-Shui Luk1, Wai-Yee Chan, Owen M Rennert

  • 1School of Biomedical Sciences, Room 622A, Lo Kwee-Seong Integrated Biomedical Sciences Building, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

Reproduction (Cambridge, England)
|April 10, 2014
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are newly identified regulators of spermatogenesis. Further research into lncRNAs offers new insights into male fertility and the development of contraceptives.

More Related Videos

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
09:40

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model

Published on: February 6, 2018

14.9K
Enhanced Crosslinking Immunoprecipitation eCLIP Method for Efficient Identification of Protein-bound RNA in Mouse Testis
10:31

Enhanced Crosslinking Immunoprecipitation eCLIP Method for Efficient Identification of Protein-bound RNA in Mouse Testis

Published on: May 10, 2019

19.4K

Related Experiment Videos

Last Updated: May 1, 2026

Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye
08:21

Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye

Published on: January 14, 2021

5.2K
A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
09:40

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model

Published on: February 6, 2018

14.9K
Enhanced Crosslinking Immunoprecipitation eCLIP Method for Efficient Identification of Protein-bound RNA in Mouse Testis
10:31

Enhanced Crosslinking Immunoprecipitation eCLIP Method for Efficient Identification of Protein-bound RNA in Mouse Testis

Published on: May 10, 2019

19.4K

Area of Science:

  • Reproductive Biology
  • Molecular Genetics
  • Developmental Biology

Background:

  • Spermatogenesis is crucial for male fertility, involving complex gene regulation.
  • Previous studies focused on protein-coding genes, largely ignoring noncoding transcripts.
  • The role of long noncoding RNAs (lncRNAs) in spermatogenesis is understudied.

Purpose of the Study:

  • To explore the role of lncRNAs in spermatogenesis.
  • To highlight lncRNAs as potential regulatory targets in male germ cell development.
  • To provide insights into molecular mechanisms of spermatogenesis.

Main Methods:

  • Review of recent transcriptome studies on spermatogenesis.
  • Analysis of noncoding RNA populations in male germ cells.
  • Identification of lncRNAs involved in spermatogenesis.

Main Results:

  • Transcriptome studies reveal a significant population of noncoding transcripts.
  • A subset of these noncoding transcripts are long noncoding RNAs (lncRNAs).
  • lncRNAs emerge as novel regulatory elements in spermatogenesis.

Conclusions:

  • lncRNAs represent a new frontier in understanding spermatogenesis.
  • Targeting lncRNAs could offer new strategies for addressing male infertility.
  • Further investigation of lncRNAs is essential for reproductive biology research.