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Updated: May 1, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
Role of non-acid reflux in patients with non-erosive reflux disease
Georgios P Karamanolis1, Radu Tutuian2
1Gastroenterology Unit, 2 Surgical Department, Aretaieion Hospital, Athens Medical School, Athens, Greece (Georgios P. Karamanolis).
Abstract:
Non-erosive reflux disease (NERD) is the most common presentation of gastroesophageal reflux disease. Although acid reflux is the most important cause of symptom generation in NERD patients, non-acid reflux is also associated with reflux symptoms. The temporal relation between symptoms and reflux episodes is of importance in evaluating the results of combined pH-impedance monitoring in NERD patients. Mucosal hypersensitivity and mechanical stimulation due to great volume of non-acid reflux are among the putative mechanisms of symptom generation.
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