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Immunocytochemistry of anaplastic carcinoma of thyroid gland
C A Beltrami1, P Criante, C Di Loreto
1Istituto di Anatomia Patologica, Cattedra di Istituzioni di Anatomia Patologica, Università degli Studi di Ancona, Italia.
Applied Pathology
|January 1, 1989
Abstract:
Twelve anaplastic thyroid carcinomas were investigated with a panel of antibodies. The squamoid and giant cell anaplastic carcinomas showed coexpression of cytokeratin and vimentin in 66% of the cases. Reactivity for A-1-AT and A-1-ACT antiserum appeared when the spindle cell component became prevalent. The antidesmoplakin antibody can be employed on cryostat sections in differential diagnosis between sarcoma and carcinoma of the thyroid.