Related Experiment Video

Updated: May 1, 2026

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
07:52

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity

Published on: November 2, 2020

6.0K

Bioinformatics analysis reveals significant genes and pathways to target for oral squamous cell carcinoma

Qian Jiang1, You-Cheng Yu, Xiao-Jun Ding

  • 1Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai, China

Asian Pacific Journal of Cancer Prevention : APJCP
|April 11, 2014
PubMed
Abstract

Insights

This study explored molecular mechanisms in oral squamous cell carcinoma (OSCC) development. Key genes and pathways were identified, offering potential therapeutic targets for OSCC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Oral squamous cell carcinoma (OSCC) is a prevalent cancer with complex molecular underpinnings.
  • Understanding the genetic and molecular alterations is crucial for developing effective therapeutic strategies.

Purpose of the Study:

  • To investigate the molecular mechanisms driving oral squamous cell carcinoma (OSCC) development.
  • To identify key genes and pathways involved in OSCC pathogenesis.

Main Methods:

  • Analysis of Affymetrix microarray data (GSE31853) to identify differentially expressed genes (DEGs) between OSCC and normal tissues.
  • Application of Gene Ontology (GO) and Protein-Protein Interaction (PPI) network analyses to understand DEG functions.
  • Statistical analysis to determine significant DEGs (logFC > 1, P < 0.05).

Main Results:

  • Identified 372 DEGs, including NNMT, BAX, MMP9, and VEGF.
  • Enriched GO terms related to nucleoplasm, DNA damage response, and DNA repair.
  • GMNN and TSPO identified as significant hub proteins; steroid biosynthesis and ketone body metabolism pathways were dysregulated.

Conclusions:

  • The identified genes and pathways are critically involved in OSCC development.
  • This research provides a comprehensive molecular perspective on OSCC.
  • The significant genes and pathways represent potential therapeutic targets for future OSCC treatment.

More Related Videos

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

6.0K
Development of Compendium for Esophageal Squamous Cell Carcinoma03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

974

Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.3K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

2.6K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.1K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K