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Published on: January 20, 2023
Monolithic chip system with a microfluidic channel for in situ electron microscopy of liquids
Eric Jensen1, Andrew Burrows2, Kristian Mølhave1
11 Technical University of Denmark, DTU Nanotech, Ørsteds Plads, Building 345E, 2800 Kgs Lyngby, Denmark.
Abstract:
Electron microscopy of enclosed liquid samples requires the thinnest possible membranes as enclosing windows as well as nanoscale liquid sample thickness to achieve the best possible resolution. Today liquid sample systems for transmission electron microscopy (TEM) are typically made from two sandwiched microchips with thin membranes. We report on a new microfabricated chip system based on a monolithic design that enables membrane geometry on the scale of a few micrometers. The design is intended to reduce membrane deflection when the system is under pressure, a microfluidic channel for improved flow geometry, and a better space angle for auxiliary detectors such as energy-dispersive X-ray spectroscopy. We explain the system design and fabrication and show the first successful TEM images of liquid samples in the chips.
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