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Updated: May 1, 2026

17:35
A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
Published on: November 1, 2013
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Update on antibacterial soaps: the FDA takes a second look at triclosans
Journal of Drugs in Dermatology : JDD
|April 11, 2014
Summary
The U.S. Food and Drug Administration is reviewing the safety of triclosan, a biocide found in many soaps. Concerns include effectiveness, antibiotic resistance, and potential hormone disruption.
Area of Science:
- Environmental science
- Toxicology
- Public health
Background:
- Triclosan, a biocide, has seen widespread use since 1972, appearing in 75% of commercial soaps.
- A significant portion of the population (76% of adults and children sampled) excretes triclosan, indicating broad exposure.
- Increased triclosan use has prompted regulatory review of over-the-counter biocides.
Purpose of the Study:
- To examine the safety and efficacy of the biocide triclosan.
- To address concerns regarding the widespread use of triclosan in consumer products.
- To inform regulatory decisions by the Food and Drug Administration and Environmental Protection Agency.
Main Methods:
- Review of existing safety data on triclosan.
- Analysis of the efficacy of triclosan compared to traditional soaps.
- Investigation into potential adverse effects, including antibiotic resistance and endocrine disruption.
Main Results:
- The Food and Drug Administration announced a review of triclosan's safety and efficacy.
- Data requests were issued to gather further safety information.
- Key concerns identified include comparative effectiveness, potential for promoting drug-resistant bacteria, and endocrine-disrupting properties.
Conclusions:
- The widespread presence and excretion of triclosan necessitate a thorough safety evaluation.
- Further research is required to understand the long-term health and environmental impacts of triclosan.
- Regulatory bodies are actively assessing the risks associated with common biocides like triclosan.
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