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Alpha-1 antitrypsin deficiency in Iranian patients with chronic obstructive pulmonary disease
Bita Geramizadeh1, Zahra Jowkar2, Leila Karami2
1Department of Pathology, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran ; Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Background:
Alpha-1 antitrypsin deficiency is a genetic disease which affects both lung and liver. This disease is a recognized factor for chronic obstructive pulmonary disease (COPD). However its importance as the cause of COPD in a country such as Iran is unclear.
Objectives:
This study was conducted to find out the role of α-1 antitrypsin deficiency as a cause of COPD in Iranian patients.
Materials And Methods:
The serum concentration of α-1 antitrypsin was determined and the genotype of α-1 antitrypsin was also evaluated by PCR-RFLP in 130 patients with COPD and 50 normal healthy blood donors.
Results:
No α-1 antitrypsin deficient case was found in normal healthy people and COPD patients.
Conclusions:
Our results clarify that deficiency of α-antitrypsin is not a major cause of COPD in Iranian patients.
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