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Cytotoxic properties of some medicinal plant extracts from mazandaran, iran
Farkhondeh Nemati1, Abbas Ali Dehpouri1, Bahman Eslami1
1Department of Biology, Qaemshahr Branch, Islamic Azad University, Qaemshahr, IR Iran.
Background:
It was shown that plants derived agents are being used for treatment of cancer. In this study, crude ethanolic extract of Consolida orientalis L., Ferula assa-foetida L., Coronilla varia L., Orobanche orientalis G. Beck were screened in vitro for cytotoxic activity on Hela (Human cervical carcinoma) cell line.
Objectives:
We performed the present study to evaluate the in vitro cytotoxic activity of four plant extracts that we gathered from north of Iran, Mazandaran.
Materials And Methods:
Hela cells were treated with various concentrations of individual samples (0.0312, 0.0625, 0.125, 0.25, 0.5, 1, 2.5, 5, 7.5 and 10 mg/ml) for 72 hours. Cell proliferation measured by MTT assay.
Results:
Result from the performed assay showed that ethanolic extract of Consolida orientalis L., Ferula assa-foetida L., Coronilla varia L. has more significant cytotoxicity effect on Hela cell line than Orobanche orientalis G. Beck.
Conclusions:
Extracts of the Consolida orientalis L., Ferula assa-foetida L., Coronilla varia L. could be considered as potential sources of anticancer compounds but further studies are necessary for isolation and identification of biologically active substances.
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