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Updated: May 1, 2026

Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
RANKL expression in periodontal disease: where does RANKL come from?
Bin Chen1, Wenlei Wu1, Weibin Sun1
1Institute and Hospital of Stomatology, Nanjing University Medical School, 30 Zhongyang Road, Nanjing, Jiangsu 210008, China.
Abstract:
Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development and osteoclast function. Therefore, RANKL plays a critical role in periodontal bone resorption. In this review, we have summarized the sources of RANKL in periodontal disease and explored which factors may regulate RANKL expression in this disease.
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