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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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T Cell Activation and Clonal Selection01:22

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Cytotoxic T Cells-mediated Immune Response01:27

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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Related Experiment Video

Updated: May 1, 2026

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
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[T-cells immunity in oral lichen planus pathogenesis].

S V Tarasenko, A I Shatokhin, K T Umbetova

    Stomatologiia
    |April 12, 2014
    PubMed
    Summary

    This review details the cell-mediated immune pathogenesis of Lichen planus (LP). It highlights molecular diagnostic methods and the link between oral LP and infectious diseases.

    Area of Science:

    • Immunology
    • Oral pathology
    • Dermatology

    Background:

    • Lichen planus (LP) is an inflammatory condition with complex pathogenesis.
    • Understanding the cell-mediated immune mechanisms is crucial for diagnosis and treatment.
    • Oral LP is a common manifestation requiring specific diagnostic approaches.

    Purpose of the Study:

    • To review current concepts of cell-mediated immune pathogenesis in Lichen planus.
    • To emphasize the role of molecular diagnostic techniques in LP.
    • To explore the association between oral LP and infectious diseases.

    Main Methods:

    • Literature review of immunological and molecular studies on Lichen planus.
    • Focus on immunohistochemical and other molecular diagnostic methods.

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  • Analysis of studies linking oral LP to infectious agents.

    • Main Results:

    • The review describes modern cell-mediated immune pathogenesis theories for LP.
    • Molecular diagnostic tools, including immunohistochemistry, are presented as key methods.
    • Evidence supporting a connection between the onset of oral LP and infectious diseases is discussed.

    Conclusions:

    • Cell-mediated immunity plays a central role in Lichen planus pathogenesis.
    • Advanced molecular diagnostics are essential for accurate LP identification.
    • Infectious diseases may contribute to the development of oral Lichen planus.