[T-cells immunity in oral lichen planus pathogenesis]

Area of Science:

• Immunology
• Oral pathology
• Dermatology

Background:

• Lichen planus (LP) is an inflammatory condition with complex pathogenesis.
• Understanding the cell-mediated immune mechanisms is crucial for diagnosis and treatment.
• Oral LP is a common manifestation requiring specific diagnostic approaches.

Purpose of the Study:

• To review current concepts of cell-mediated immune pathogenesis in Lichen planus.
• To emphasize the role of molecular diagnostic techniques in LP.
• To explore the association between oral LP and infectious diseases.

Main Methods:

• Literature review of immunological and molecular studies on Lichen planus.
• Focus on immunohistochemical and other molecular diagnostic methods.
• Analysis of studies linking oral LP to infectious agents.

Main Results:

• The review describes modern cell-mediated immune pathogenesis theories for LP.
• Molecular diagnostic tools, including immunohistochemistry, are presented as key methods.
• Evidence supporting a connection between the onset of oral LP and infectious diseases is discussed.

Conclusions:

• Cell-mediated immunity plays a central role in Lichen planus pathogenesis.
• Advanced molecular diagnostics are essential for accurate LP identification.
• Infectious diseases may contribute to the development of oral Lichen planus.