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Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Basal Lamina are the Specialized Form of ECM01:03

Basal Lamina are the Specialized Form of ECM

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The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.
Proteins...
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Cells of the Epidermis01:24

Cells of the Epidermis

7.2K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
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Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
2.9K
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

2.5K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
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Related Experiment Video

Updated: May 1, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

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Basal cell carcinoma.

Aditya K Gupta, Deanne Daigle, George Martin

    Skinmed
    |April 12, 2014
    PubMed
    Summary

    New biologic therapies show promise for advanced basal cell carcinoma (BCC) when surgery or radiation are not options. These targeted treatments offer a potential new avenue for managing difficult BCC cases.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Dermatology

    Background:

    • Basal cell carcinoma (BCC) is a common skin cancer.
    • Advanced BCC, including locally advanced and metastatic forms, presents treatment challenges.
    • Traditional therapies like chemotherapy and radiation have limited efficacy for advanced BCC.

    Purpose of the Study:

    • To review the emerging role of biologic therapies in treating advanced basal cell carcinoma.
    • To highlight molecular pathways implicated in BCC pathogenesis.
    • To assess the preliminary evidence for new treatment modalities.

    Main Methods:

    • Review of recent molecular biology discoveries in BCC.
    • Identification of key signaling pathways (EGFR, hedgehog).
    • Evaluation of preliminary data on biologic therapies for advanced BCC.

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    Last Updated: May 1, 2026

    Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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    Cell Population Analyses During Skin Carcinogenesis
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    Main Results:

    • Biologic therapies targeting EGFR and hedgehog pathways are under investigation.
    • Preliminary evidence suggests disease stabilization with these new agents.
    • Limited phase II and III trial data are currently available.

    Conclusions:

    • Biologic therapies represent a promising new treatment strategy for advanced BCC.
    • Targeting specific molecular pathways offers a novel approach.
    • Further clinical trials are needed to confirm efficacy and safety.