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Published on: September 25, 2019
Focal subarachnoid haemorrhage mimicking transient ischaemic attack--do we really need MRI in the acute stage?
Lorenz Ertl1, Dominik Morhard, Maria Deckert-Schmitz
1Department of Radiology, Nuclear Medicine & Neuroradiology, Klinikum München-Harlaching, Sanatoriumsplatz 2, Munich D-81545, Germany. lorenz.ertl@med.uni-muenchen.de.
Background:
Acute non-traumatic focal subarachnoid haemorrhage (fSAH) is a rare transient ischaemic attack (TIA)-mimic. MRI is considered to be indispensable by some authors in order to avoid misdiagnosis, and subsequent improper therapy. We therefore evaluated the role of CT and MRI in the diagnosis of fSAH patients by comparing our cases to those from the literature.
Methods:
From 01/2010 to 12/2012 we retrospectively identified seven patients with transient neurological episodes due to fSAH, who had received unenhanced thin-sliced multiplanar CT and subsequent MRI within 3 days on a 1.5 T scanner. MRI protocol included at least fast-field-echo (FFE), diffusion-weighted imaging (DWI), T2-weighted fluid-attenuated inversion recovery (FLAIR) and time-of-flight (TOF) MRA sequences. By using MRI as gold-standard, we re-evaluated images and data from recent publications regarding the sensitivity to detect fSAH in unenhanced CT.
Results:
fSAH was detected by CT and by FFE and FLAIR on MRI in all of our own cases. However, DWI and T2w-spin-echo sequences revealed fSAH in 3 of 7 and 4 of 6 cases respectively. Vascular imaging was negative in all cases. FFE-MRI revealed additional multiple microbleeds and superficial siderosis in 4 of 7 patients and 5 of 7 patients respectively. Including data from recently published literature CT scans delivered positive results for fSAH in 95 of 100 cases (95%), whereas MRI was positive for fSAH in 69 of 69 cases (100%).
Conclusions:
Thin-sliced unenhanced CT is a valuable emergency diagnostic tool to rule out intracranial haemorrhage including fSAH in patients with acute transient neurological episodes if immediate MRI is not available. However, MRI work-up is crucial and mandatorily has to be completed within the next 24-72 hours.
Insights
Thin-sliced CT effectively diagnoses focal subarachnoid hemorrhage (fSAH), a TIA mimic, when MRI is unavailable. However, MRI remains crucial for definitive diagnosis within 24-72 hours.
Area of Science:
- Neurology
- Radiology
- Emergency Medicine
Background:
- Acute non-traumatic focal subarachnoid hemorrhage (fSAH) mimics transient ischemic attack (TIA).
- Early and accurate diagnosis is critical to prevent misdiagnosis and improper treatment.
- The diagnostic roles of CT and MRI for fSAH require evaluation.
Purpose of the Study:
- To evaluate the diagnostic accuracy of CT and MRI in patients with fSAH.
- To compare the sensitivity of CT and MRI in detecting fSAH.
- To assess the utility of CT as an emergency tool for fSAH.
Main Methods:
- Retrospective analysis of seven fSAH patients with CT and MRI within 3 days.
- MRI protocol included FFE, DWI, FLAIR, and TOF MRA sequences.
- Literature review to compare CT and MRI sensitivity for fSAH detection.
Main Results:
- CT and FFE/FLAIR MRI detected fSAH in all seven own cases.
- CT sensitivity for fSAH was 95% (95/100 cases) in literature data.
- MRI sensitivity for fSAH was 100% (69/69 cases) in literature data.
- MRI revealed additional microbleeds and superficial siderosis in some patients.
Conclusions:
- Thin-slice unenhanced CT is a valuable emergency tool for ruling out intracranial hemorrhage, including fSAH.
- MRI is crucial for definitive fSAH diagnosis and should be completed within 24-72 hours.
- CT can serve as an initial diagnostic step when immediate MRI is not feasible.
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