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Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

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Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
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Pneumonia I: Introduction01:29

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Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
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Pneumonia I: Introduction01:30

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Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
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The pathophysiology of pneumonia involves the following steps:
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Atypical Pneumonia01:14

Atypical Pneumonia

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Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
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Pneumonia III: Complications and Assessment01:30

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Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
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Related Experiment Video

Updated: May 1, 2026

A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice
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Matrix metalloproteinases in pneumonia.

Ting-Yen Chiang1, Shih-Ming Tsao2, Chao-Bin Yeh3

  • 1School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|April 12, 2014
PubMed
Summary

Matrix metalloproteinases (MMPs) are key factors in pneumonia's development, contributing to significant morbidity and mortality. Understanding MMP roles is crucial for improving pneumonia treatment outcomes.

Keywords:
Matrix metalloproteinasePneumonia

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Area of Science:

  • Biochemistry
  • Pathology
  • Infectious Diseases

Background:

  • Pneumonia causes significant global morbidity and mortality, with high fatality rates in hospital-acquired infections.
  • Despite advances in antibiotics and intensive care, pneumonia mortality remains a critical issue.
  • Matrix metalloproteinases (MMPs) are enzymes degrading extracellular matrix (ECM) and play roles in inflammation and infection.

Purpose of the Study:

  • To provide an overview of matrix metalloproteinases (MMPs) expressed in pneumonia.
  • To review the pathological roles of various MMPs in different types of pneumonia.

Main Methods:

  • Literature review of studies on MMPs and pneumonia.
  • Schematic overview of MMP expression in pneumonia.

Main Results:

  • MMPs are implicated in the pathogenesis of community-acquired, hospital-acquired, and ventilator-associated pneumonia.
  • MMPs contribute to the inflammatory and infectious processes in pneumonia.

Conclusions:

  • MMPs are critical factors in the development and progression of pneumonia.
  • Further research into MMPs may lead to improved therapeutic strategies for pneumonia.