Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thermosensation01:43

Thermosensation

29.7K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
29.7K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

6.6K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
6.6K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

5.8K
5.8K
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

5.5K
GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
5.5K
Regulation of Heart Rates01:31

Regulation of Heart Rates

6.0K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
6.0K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

5.4K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myristoylated Neuronal Calcium Sensor-1 captures the preciliary vesicle at distal appendages.

eLife·2025
Same author

Myristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages.

bioRxiv : the preprint server for biology·2023
Same author

Biophysical physiology of phosphoinositide rapid dynamics and regulation in living cells.

The Journal of general physiology·2022
Same author

Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis.

The Journal of general physiology·2022
Same author

Control of Neuronal Excitability by Cell Surface Receptor Density and Phosphoinositide Metabolism.

Frontiers in pharmacology·2021
Same author

Translational investigation of electrophysiology in hypertrophic cardiomyopathy.

Journal of molecular and cellular cardiology·2021

Related Experiment Video

Updated: May 1, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

9.8K

TRPM4 channels in the cardiovascular system.

Martin Kruse1, Olaf Pongs2

  • 1Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.

Current Opinion in Pharmacology
|April 12, 2014
PubMed
Summary

Mutations in the Transient Receptor Potential Melastatin 4 (TRPM4) channel cause heart rhythm disorders. TRPM4 channel dysfunction offers a new therapeutic target for cardiac conditions.

More Related Videos

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

8.6K
A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

14.8K

Related Experiment Videos

Last Updated: May 1, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

9.8K
Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

8.6K
A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

14.8K

Area of Science:

  • Cardiology
  • Molecular Biology
  • Genetics

Background:

  • The Transient Receptor Potential Melastatin 4 (TRPM4) cation channel is crucial for cardiac rhythmicity, affecting conduction, pacemaking, and repolarization.
  • TRPM4 is highly expressed in cardiac cells, playing a vital role in maintaining normal heart function.

Purpose of the Study:

  • To investigate the role of TRPM4 mutations in cardiac disorders and explore its potential as a therapeutic target.
  • To understand the link between TRPM4 gene mutations and inherited cardiac conditions.

Main Methods:

  • Analysis of genetic mutations in the TRPM4 gene.
  • Phenotypic characterization of cardiac disorders associated with TRPM4 mutations.
  • Comparison of TRPM4-related phenotypes with those linked to SCN5A mutations.

Main Results:

  • Dominant TRPM4 mutations cause progressive familial heart block type I (PFHBI) and isolated cardiac conduction disease (ICCD).
  • Associated conditions include atrio-ventricular conduction block, right bundle branch block, bradycardia, and Brugada syndrome.
  • TRPM4 mutant phenotypes mimic those caused by SCN5A mutations, highlighting functional overlap.

Conclusions:

  • TRPM4 channel dysfunction is implicated in several inherited cardiac conduction disorders.
  • The TRPM4 channel, and its interaction with sulfonylurea-receptors (SURs), represents a promising novel therapeutic target for treating cardiac rhythm abnormalities.