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High-dose vaginal maintenance metronidazole for recurrent bacterial vaginosis: a pilot study
Tina Aguin1, Robert A Akins, Jack D Sobel
1From the Departments of *Obstetrics and Gynecology, †Biochemistry and Molecular Biology, and ‡Infectious Diseases, Wayne State University School of Medicine, Detroit, MI.
Abstract:
The purpose of this study was to explore the benefit of high-dose intravaginal metronidazole as a maintenance therapy in reducing recurrence rates of bacterial vaginosis (BV). Eighteen women with a history of recurrent BV and symptomatic BV were treated with metronidazole 750 mg suppository intravaginally daily for 7 days. Those in remission by Amsel criteria received metronidazole 750 mg twice weekly for 3 months with further follow-up for 3 months. High-dose metronidazole intravaginally was associated with rare clinical recurrence during the period of use. After cessation of suppression therapy, recurrence was high.
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