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Related Experiment Video

Updated: May 1, 2026

Author Spotlight: Fabrication of a Low-Cost, Fiber-Coupled, and Air-Spaced Fabry-Pérot Etalon

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Double-pass Mach-Zehnder fiber interferometer pH sensor.

Zhi Qiang Tou¹, Chi Chiu Chan¹, Jesmond Hong¹

¹Nanyang Technological University, School of Chemical and Biomedical Engineering, Division of Bioengineering, 70 Nanyang Drive, Singapore 637457, Singapore.

Journal of Biomedical Optics

|April 12, 2014

Summary

This summary is machine-generated.

This study introduces a novel fiber-optic pH sensor using a Mach-Zehnder interferometer. The biocompatible sensor accurately monitors pH in cell cultures, offering high sensitivity and a low detection limit for cancer research.

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Area of Science:

Biomedical Engineering
Optical Sensing
Materials Science

Background:

Accurate real-time pH monitoring is crucial for biological and chemical processes.
Existing pH sensors may face limitations in biocompatibility, sensitivity, or application scope.
Fiber-optic sensors offer potential advantages in remote sensing and harsh environments.

Purpose of the Study:

To develop and characterize a novel biocompatible fiber-optic pH sensor.
To investigate the sensor's performance in terms of sensitivity, detection limit, and stability.
To demonstrate the sensor's utility in monitoring pH in cell culture for cancer research.

Main Methods:

Fabrication of a double-pass Mach-Zehnder interferometer with a pH-responsive hydrogel coating.
Utilizing poly(2-hydroxyethyl methacrylate-co-2-(dimethylamino)ethyl methacrylate) hydrogel for pH sensitivity.
Testing the sensor in phosphate buffer saline and applying it to monitor cell culture media pH.

Main Results:

The sensor demonstrated high sensitivity (1.71 nm/pH) and a low limit of detection (0.004 pH).
The sensor exhibited good responsiveness, repeatability, and stability.
Successful application in monitoring cell culture media pH to study cancer cell growth.

Conclusions:

The proposed fiber-optic pH sensor is biocompatible, sensitive, and stable.
This technology offers a promising tool for real-time pH monitoring in biological applications, including cancer research.
The sensor's performance validates its potential for investigating the relationship between pH and cancer cell proliferation.