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Multiple uncommon chromosome abnormalities in acute myelomonocytic leukemia (AMMoL-M4) with rapid progression
O Haus1, M Podolak-Dawidziak, M Sasiadek
1Department of Pathophysiology, Medical Academy, Wrocław, Poland.
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1989
Abstract:
We observed multiple uncommon chromosome abnormalities resulting in marker formation in a patient with AMMoL-M4. The breakpoints of the aberrations corresponded to common "cancer breakpoints" described by Mitelman and also--to localisation of some protooncogenes. The activation of these multiple protooncogenes in the described case might result in rapid progression of the disease and in the resistance to therapy.