Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

4.7K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
4.7K
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

3.2K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
3.2K
Membrane Fluidity01:26

Membrane Fluidity

14.0K
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
14.0K
Membrane Fluidity01:23

Membrane Fluidity

150.1K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
150.1K
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

7.8K
The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
7.8K
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

3.0K
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-trapping of microorganisms steering toward their own trail.

Physical review. E·2026
Same author

Multibody interactions between protein inclusions in the pointlike curvature model for tense and tensionless membranes.

The European physical journal. E, Soft matter·2024
Same author

Cycling and spiral-wave modes in an active cyclic Potts model.

The Journal of chemical physics·2024
Same author

Field-mediated interactions of passive and conformation-active particles: multibody and retardation effects.

Soft matter·2022
Same author

Binding of thermalized and active membrane curvature-inducing proteins.

Soft matter·2021
Same author

Mass spectrometry - based imaging techniques for iodine-127 and iodine-129 detection and localization in the brown alga Laminaria digitata.

Journal of environmental radioactivity·2021

Related Experiment Video

Updated: May 1, 2026

Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions
10:02

Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions

Published on: May 27, 2021

3.4K

Dynamics of the force exchanged between membrane inclusions.

Jean-Baptiste Fournier1

  • 1Université Paris Diderot, Sorbonne Paris Cité, Laboratoire Matière et Systèmes Complexes (MSC), UMR 7057 CNRS, F-75205 Paris, France.

Physical Review Letters
|April 15, 2014
PubMed
Summary

Active inclusions in fluid membranes generate strong, transient forces much larger than equilibrium forces. This dynamical interaction is long-range, even with membrane tension, and is influenced by friction.

More Related Videos

Measurement of Force-Sensitive Protein Dynamics in Living Cells Using a Combination of Fluorescent Techniques
08:28

Measurement of Force-Sensitive Protein Dynamics in Living Cells Using a Combination of Fluorescent Techniques

Published on: November 2, 2018

7.8K
Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence TIRF Microscopy
08:55

Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence TIRF Microscopy

Published on: February 17, 2023

4.4K

Related Experiment Videos

Last Updated: May 1, 2026

Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions
10:02

Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions

Published on: May 27, 2021

3.4K
Measurement of Force-Sensitive Protein Dynamics in Living Cells Using a Combination of Fluorescent Techniques
08:28

Measurement of Force-Sensitive Protein Dynamics in Living Cells Using a Combination of Fluorescent Techniques

Published on: November 2, 2018

7.8K
Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence TIRF Microscopy
08:55

Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence TIRF Microscopy

Published on: February 17, 2023

4.4K

Area of Science:

  • Soft matter physics
  • Biophysics
  • Membrane dynamics

Background:

  • Fluid membranes are dynamic structures crucial for biological processes.
  • Active inclusions can alter membrane properties and behavior.
  • Understanding membrane-fluid interactions is key to cell function.

Purpose of the Study:

  • To investigate the dynamical response of fluid membranes to active inclusions.
  • To analyze the forces and interaction ranges between active inclusions.
  • To elucidate the role of membrane properties and friction in these dynamics.

Main Methods:

  • Analytical derivation of scaling laws.
  • Modeling the linear coupling between inclusions and membrane curvature.
  • Considering intermonolayer friction effects.

Main Results:

  • Active inclusions induce transient forces exceeding equilibrium forces.
  • Dynamical interactions exhibit long-range behavior beyond the correlation length.
  • Intermonolayer friction significantly impacts the observed phenomena.

Conclusions:

  • Sudden conformation changes in active inclusions lead to significant, long-range dynamical forces in fluid membranes.
  • Membrane tension does not suppress this long-range interaction.
  • Intermonolayer friction is a critical factor in understanding these membrane-inclusion dynamics.