Enantioselective synthesis of an HCV NS5a antagonist
Ian K Mangion1, Cheng-yi Chen, Hongmei Li
1Department of Process Chemistry, Merck and Co., Inc. , P.O. Box 2000, Rahway, New Jersey 07065, United States.
Organic Letters
|April 15, 2014
Abstract:
A concise, enantioselective synthesis of the HCV NS5a inhibitor MK-8742 (1) is reported. The features of the synthesis include a highly enantioselective transfer hydrogenation of an NH imine and a dynamic diastereoselective transformation. The synthesis of this complex target requires simple starting materials and nine linear steps for completion.


