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Metachronous benign ovarian tumors are not uncommon in children

Seppo Taskinen1, Alda Urtane1, Riitta Fagerholm1

  • 1Department of Pediatric Surgery, Children's Hospital, University of Helsinki, Helsinki, Finland.

Journal of Pediatric Surgery
|April 15, 2014
PubMed

Insights

Pediatric patients with mature ovarian teratoma have a significant risk of developing a metachronous contralateral ovarian tumor. Yearly ultrasounds are recommended for early detection and fertility preservation.

Area of Science:

  • Gynecology
  • Pediatric Oncology

Background:

  • Mature ovarian teratomas are common germ cell tumors in pediatric patients.
  • Risk of contralateral ovarian tumor development requires further investigation.

Purpose of the Study:

  • To assess the incidence and risk of metachronous ovarian tumors in pediatric patients previously treated for mature ovarian teratoma.

Main Methods:

  • Retrospective analysis of 22 pediatric patients who underwent oophorectomy for mature teratoma between 1981 and 2011.
  • Median follow-up duration of 4.4 years.

Main Results:

  • 23% of patients developed a metachronous contralateral ovarian tumor during follow-up.
  • Kaplan-Meier analysis indicated a 14% ± 8% risk of contralateral tumor within five years and 66% ± 26% within 10 years.
  • Metachronous tumors included mature teratomas and seromucinous infantile cystadenomas; all treated with ovary-preserving surgery.

Conclusions:

  • A substantial proportion of pediatric patients with ovarian mature teratoma develop metachronous contralateral tumors.
  • Yearly ultrasound surveillance is crucial for early diagnosis, enabling fertility-sparing management.
Abstract

Keywords:
ChildrenContralateral tumorCystadenomaMetachronous tumorTeratoma

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